Ethicon DNX12 - Adhesive Dermabond Advanced Applicator Topical 12/Bx

Ethicon DNX12 – Adhesive Dermabond Advanced Applicator Topical 12/Bx

Dermabond Advanced Topical Skin Adhesive – Unique Formulation with an Easy-To-Use Applicator for Precise Control for Wide and Fine Line Applications; 0.7ml Adhesive Volume

DERMABOND ADVANCED Adhesive is a wound closure device that adds strength when used in conjunction with deep dermal stitches after strength, provides a protective barrierand demonstrated in vitro inhibits bacteria.

DERMABOND ADVANCED Adhesive is intended for topical application only, to hold closed easily approximated skin edges of wounds from surgical incisions, including incisions from minimally invasive surgery, and simple, thoroughly cleansed, trauma-induced lacerations.DERMABOND ADVANCED Adhesive may be used in conjunction with, but not in place of, deep dermal stitches.

Features & Benefits

Additional Strength for Secure Closure When used in addition to sutures, DERMABOND ADVANCED Adhesive was shown ex vivo to add 75% more strength to wound closure than sutures alone.	Microbial Barrier Protection DERMABOND ADVANCED Adhesive provides a microbial barrier with 99% protection in vitro for at least 72 hours against organisms commonly responsible for surgical site infections (SSIs

Indications

DERMABONDADVANCED Adhesive is intended for topical application only, to hold closed easily approximated skin edges of wounds from surgical incisions, including incisions from minimally invasive surgery, and simple, thoroughly cleansed, trauma-induced lacerations. DERMABONDADVANCED Adhesive may be used in conjunction with, but not in place of, deep dermal stitches.

Contraindications

• Do not use on any wound with evidence of active infection, gangrene, or wounds of decubitus etiology.
• Do not use on mucosal surfaces or across mucocutaneous junctions (e.g., oral cavity, lips), or on skin which may be regularly exposed to body fluids or with dense natural hair (e.g. scalp).
• Do not use on patients with a known hypersensitivity to cyanoacrylate, formaldehyde, or benzalkonium chloride.

In Vivo Study of Wound Bursting Strength and Compliance of Topical Skin Adhesives

The purpose of this study was to evaluate the wound-bursting strength and flexibility of five topical skin adhesives during the two-day period after wound closure.

The following adhesives were evaluated in the study:

• DERMABOND Topical Skin Adhesive
• INDERMIL Tissue Adhesive
• Histoacryl Topical Skin Adhesive
• LiquiBand Topical Skin Adhesive
• GluStitch

Methods

Using a template for incision length and location, two symmetric incisions (2 cm long each) were created over the dorsolateral flank area of 210 anesthetized, male Sprague-Dawley rats. After achieving hemostasis and manually approximating the skin edges, a randomized computer algorithm was used to select an adhesive to close the incision. All adhesives were applied according to manufacturer instructions. The adhesives were evaluated three times during the study immediately after closure, 1 day after closure, and 2 days after closure. For each evaluation, 14 samples from each adhesive group were tested for wound-bursting strength, and another 14 samples were tested for flexibility. To test for wound-bursting strength, a vacuum chamber was placed over each sample and negative pressure was applied, stressing the wound in 3 dimensions. The pressure (mmHg) needed to cause wound failure was recorded. To test for flexibility, a vacuum chamber was placed over the sample and negative pressure was applied to the wound while a laser measured the vertical deformation of the skin (m). Energy absorption (mmHg x mm) was calculated to quantify the adhesives flexibility.

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Sterile Single Use Only